Swiss Ageing Citizen reference Cohort (SACR)

The project aims to investigate broad risk patterns of accelerated aging, and the mechanisms that mediate identified risk patterns. These investigations will be in the context of a testable and scalable public health platform (Swiss Ageing Citizen Reference; SACR) to strengthen personalized health and exposome research, via making biosamples and data available for personalized health researchers. The SACR will have a subset of participants from three existing Swiss citizen cohorts at its core. The citizen cohorts include SAPALDIA (Swiss cohort study on air pollution and lung and heart diseases in adults), SKIPOGH (Swiss kidney project on genes in hypertension), and CoLaus|PsyCoLaus (Lausanne cohort on risk factors for cardiovascular diseases and mental disorders).

Information and biomaterial obtained in the context of several cohort-specific follow-up examinations, linked to broad research consent, will become inter-operable and searchable via the SACR meta-database. Archived biomaterial and data from SACR participants will be accessible for testing the clinical and public health utility of candidate biomarkers and exposome features in predicting bio-age (DNA methylation; MRI-derived brain features) and age-related (multi-) morbidities.